Ben's paper was published today in the 2010 proceedings of the Pacific Symposium in Biocomputing.  You can download the PDF here.

A tip of the hat to a commenter on my previous coverage of a next-gen sequencing paper for pointing out this detailed and perhaps more technically-oriented review on sequencing by synthesis recently published in Nature Biotechnology.  Thanks, Clive. Review: The challenges of sequencing by synthesis (Nature Biotechnology)Getting Genetics Done by Stephen Turner is licensed under a Creative Commons Attribution (CC BY) License.

Following up on last week's coverage of the Genotyping Portal, check out this new review article on next-generation sequencing in Nature Reviews Genetics.  One major focus of this paper is that the next generation of sequencing platforms each use fundamentally different technologies.

The New York Times had an interesting piece yesterday about how SAS is facing several business threats from companies like the recently IBM-acquired SPSS, and from burgeoning interest in open-source software like R.

There are no common disorders - only extremes of quantitative traits. --- That's the argument made by Plomin, Haworth, and Davis in a great review paper just published online in Nature Reviews Genetics.

The Elements of Statistical Learning: Data Mining, Inference, and Prediction by Trevor Hastie, Robert Tibshirani, and Jerome Friedman, one of the best books on data mining and machine learning, is now available free in PDF format. Download it here or view it online here.Getting Genetics Done by Stephen Turner is licensed under a Creative Commons Attribution (CC BY) License.

Dan Vorhaus and Lawrence Moore recently put together this excellent three part series on Genomics Law Report.  Headlines about deCODE Genetics on the brink of insolvency and major shifts in the upper management of 23andMe inspired this series of posts on what would happen when a direct-to-consumer (DTC) genomics company goes declares bankruptcy.

As far as I know there are 3 different systems for producing figures in R: (1) base graphics, included with R, (2) the lattice package, and (3) ggplot2, one of the newer plotting systems which is, according to the creator Hadley Wickham, "based on the grammar of graphics, which tries to take the good parts of base and lattice graphics and none of the bad parts.

Nice review on the genetics of quantitative traits with good figures and references published this morning in Nature Reviews Genetics. Abstract:The genetics of quantitative traits: challenges and prospects (NRG AOP)Getting Genetics Done by Stephen Turner is licensed under a Creative Commons Attribution (CC BY) License.

Bioinformatics is running a special issue on next generation sequencing, featuring lots of papers on alignment, assembly, Chip-Seq, RNA-Seq, and other related topics. This "virtual issue" will be continually updated as more developments are made. From the editors:Bioinformatics: Next generation sequencing issueGetting Genetics Done by Stephen Turner is licensed under a Creative Commons Attribution (CC BY) License.