I’ve been blogging about genetics, statistics, computational biology, data science, and science in general for over 15 years. I published my first blog post on Getting Genetics Done in 2009, and started this blog last year after taking a few years off. Science blogging has significantly contributed to my personal and professional growth as a scientist. Writing takes time and effort — time I could have spent elsewhere.

I'm still catching up on papers from my late 2024 backlog. This week’s recap highlights a browser application for visualizing pathogen dispersal, a DNA language model evaluation benchmark on regulatory DNA, regularized ensemble polygenic risk prediction with GWAS summary statistics, multimodal analysis of RNA-seq data for complex trait genetics, and a deep dive on blastp’s E-value.

Something a little different for this week’s recap. I’ve been thinking a lot lately about the practice of data science education in this era of widely available (and really good!) LLMs for code. Commentary at the top based on my own data science teaching experience, with a deep dive into a few recent papers below.

The majority of developers use LLMs to help write code, present company included. When I’m working in languages I know well, they're fantastic at handling the grunt work: generating boilerplate, suggesting completions, and writing tedious tests and documentation.

I'm still catching up on papers from my late 2024 backlog. This week’s recap highlights autonomous microbial sensors for detecting TNT in soil, genome size estimation from long reads, STABIX for indexing and compressing GWAS summary statistics, and Clair3-RNA for deep learning-based small variant calling on long-read RNA-seq data.

OpenAI introduced the ability to create custom GPTs back in November 2023. I wanted to try to create one of these, and in the spirit of learning in public this post describes how I made it. But first, what does it do?Gene Info Custom GPT Gene Info custom GPT The Gene Info custom GPT takes a list of human gene symbols as input.

Happy New Year! I’m still catching up on papers from my late 2024 backlog.

Background Bluesky, atrrr, local LLMs I’ve written a few posts lately about Bluesky — first, Bluesky for Science, about Bluesky as a home for Science Twitter expats after the mass eXodus, another on using the atrrr package to expand your Bluesky network. I’ve also spent some time looking at R packages to provide an interface to Ollama.

I had good intentions to give NaNoWriMo a try this year but didn’t get very far. Instead I gave OpenAI’s Creative Writing Coach GPT a try for a (very) short story I had in mind, inspired by my frustration trying to access closed-access research articles for a review article I’m preparing.

The Baader–Meinhof phenomenon (aka the frequency illusion) is the name for that thing that happens when you buy a new car, and suddenly you notice that same model car everywhere you drive.