The previously mentioned Regression Modeling Strategies short course taught by Frank Harrell is nearly over. Here are the handouts (PDF) from the course. Keep an eye out here, I'll be writing a few more posts in the near future on topics Frank covered in this course.Getting Genetics Done by Stephen Turner is licensed under a Creative Commons Attribution (CC BY) License.
A new paper in Nature by the Wellcome Trust Case Control Consortium examining 16,000 cases of 8 common diseases and 3000 shared controls finds that common CNVs probed on existing arrays are well tagged by SNPs and are unlikely to contribute much to common human disease.
A District Court handed down a summary judgment invalidating most of Myriad's claims to both the BRCA1 DNA sequence and the method of testing for early-onset familial breast and ovarian cancer. See Genetic Future and Genomics Law Report for analysis.Getting Genetics Done by Stephen Turner is licensed under a Creative Commons Attribution (CC BY) License.
VICC's retreat this year is Tuesday, May 11, 2010. The theme of the retreat looks interesting: "Genomic Approaches for Personalized Medicine." You can register free here. VICC retreat: Genomic Approaches for Personalized MedicineGetting Genetics Done by Stephen Turner is licensed under a Creative Commons Attribution (CC BY) License.
Hadley Wickham, creator of ggplot2, has posted a 2 hour video on data visualization using R. You can find links to the videos and slides over at Revolutions Blog. Check back here soon. I am working with Hadley to arrange a day-long ggplot2 short course here at Vanderbilt this summer.
*** Update April 25, 2011: This code has gone through a major revision. Please see the updated code and tutorial here. *** A few months ago I showed you in this post how to use some code I wrote to produce manhattan plots in R using ggplot2. The qqman() function I described in the previous post actually calls another function, manhattan(), which has a few options you can set.
Just caught this on the OpenHelix Blog. In an interview with Charlie Rose, NIH director Francis Collins said Computational biologists will be the "breakthrough" artists of the future. Getting Genetics Done by Stephen Turner is licensed under a Creative Commons Attribution (CC BY) License.
While reading through an article on job hunting success on Bitesize Bio I stumbled upon another piece there that's definitely in the spirit of "getting things done" in genetics research. I had always halfway considered going into business manufacturing lab supplies. Take a $10 Easy-Bake Oven and add a little bit tighter temperature regulation, call it a hybridization oven, and sell it for thousands.
Vanderbilt Epidemiology Center, Institute for Medicine and Public Health presents: "Pathway-based analysis for genome-wide association studies" Steven Chen Ph.D Assistant Professor of Biostatistics Tuesday, March 16, 2010 9:00 AM - 10:00 AM 2525 West End Avenue 6th Floor BoardroomGetting Genetics Done by Stephen Turner is licensed under a Creative Commons Attribution (CC BY) License.
Here are the papers we talked about in yesterday's Journal Club:Genome Biol. 2009; 10(11): R134Searching for SNPs with cloud computing.Langmead B, Schatz MC, Lin J, Pop M, Salzberg SL.Table of Contents, Nature Methods, Visualization Supplement.Am J Hum Genet.
This Thursday's discovery lecture looks interesting. In case you missed last week's Nobel laureate, you can watch the recording from Cech's talk or any of the previous lectures in the discovery series here.