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Henry Rzepa's Blog

Henry Rzepa's Blog
Chemistry with a twist
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Chemical ITAcademic PublishingApplied LinguisticsArticle Processing ChargeBritish National CorpusChimicaInglese
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The topic of open citations was presented at the PIDapalooza conference and represents a third component in the increasing corpus of open scientific information. David Shotton gave us an update on  Citations as First Class data objects – Citation Identifiers and introduced (me) to the blog where he discusses this topic.

Chemical ITAcademic PublishingAndy MabbettDigital Object IdentifierIdentifiersChimicaInglese
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Another occasional conference report (day 1). So why is one about “persistent identifiers” important, and particularly to the chemistry domain? The PID most familiar to most chemists is the DOI (digital object identifier). In fact there are many; some 60 types have been collected by ORCID (themselves purveyors of researcher identifiers). They sometimes even have different names;

GeneralChemistryDerek LoweDeuterated DrugDrugChimicaInglese
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I don’t normally write about the pharmaceutical industry, but I was intrigued by several posts by Derek Lowe (who does cover this area) on the topic of creating new drugs by deuterating existing ones. Thus he covered the first deuterated drug receiving FDA approval last year, having first reviewed the concept back in 2009. So when someone introduced me to sila-haloperidol , I checked to see if Derek had written about it.

Interesting ChemistryBiochemistryBiologyChemistryChiralityChimicaInglese
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The title here is from an article on metalenses[cite]10.1021/acs.nanolett.6b01897[/cite] which caught my eye. Metalenses are planar and optically thin layers which can be manufactured using a single-step lithographic process. This contrasts with traditional lenses that are not flat and where the optical properties result from very accurately engineered curvatures, which in turn are expensive to manufacture.

HypervalencyChemical BondingChemistryDiazoDiazo CompoundsChimicaInglese
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Recollect the suggestion that diazomethane has hypervalent character[cite]10.1039/C5SC02076J[/cite]. When I looked into this, I came to the conclusion that it probably was mildly hypervalent, but on carbon and not nitrogen. Here I try some variations with substituents to see what light if any this casts.

HypervalencyInteresting ChemistryCandidate For Hypervalent CarbonChemical BondingHypervalent MoleculeChimicaInglese
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In the previous post, I referred to a recently published review on hypervalency[cite]10.1039/C5SC02076J[/cite] which introduced a very simple way (the valence electron equivalent γ) of quantifying the effect. Diazomethane was cited as one example of a small molecule exhibiting hypervalency (on nitrogen) by this measure.

HypervalencyAlkalideAmmoniumAnionsAtomic PhysicsChimicaInglese
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Alkalides are anionic alkali compounds containing e.g. sodide (Na–), kalide (K–), rubidide (Rb–) or caeside (Cs–). Around 90 examples can be found in the Cambridge structure database (see DOI: 10.14469/hpc/3453  for the search query and results). So what about the ammonium analogue, ammonide (NH4–)? A quick search of Scifinder drew a blank!

HypervalencyChimicaInglese
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An article with the title shown above in part recently appeared.[cite]10.1038/s41598-017-02687-z[/cite] Given the apparent similarity of HF 1- to CH 3 F 1- and CH 3 F 2- , the latter of which I introduced on this blog previously, I thought it of interest to apply my analysis to HF 1- . The authors[cite]10.1038/s41598-017-02687-z[/cite] conclude that “ the F atom of HF

Chemical ITCrystal_structure_miningComputingContextDataChimicaInglese
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FAIR data is increasingly accepted as a description of what research data should aspire to; **F**indable, **A**ccessible, **I**nter-operable and R e-usable, with Context added by rich metadata (and also that it should be Open). But there are two sides to data, one of which is the raw data emerging from say an instrument or software simulations and the other in which some kind of model is applied to produce semi-