Exploring how tech, policy, people, and ideas are connected. A special love for AI and biotechnology, but a lot of thinking about how emerging technologies like fusion, AI, quantum, and more are impacting our lives. With some sci-fi thrown in.

Some stories stick with me. This one’s been in my bones for a long time. I hope it lands with you the way it did with me.

On the Wings of a Pig

Join me for an advanced reader copy of Synthetic Eden and be one of the first in the world to read my full debut novel

Synthetic Eden is Coming — ARC Readers Wanted

Ep 35 - Out-Innovate or Be Outpaced: The Biotech Innovation Imperative

Velvet Eclipse

In a world where biology powers geopolitics, one analyst must help rewire the United States into a resilient, decentralized biomanufacturing force.

The Genome in Fifty Pieces

The Fifth Pillar

The question isn’t whether fiction influences policy. It’s how consciously we use it.

Ep 29 - Science Fiction in a Suit, Policy in a T-Shirt

On the launch of Book 2 in the Echoes of Tomorrow series — and why storytelling belongs in the rooms where we decide the future of technology.

Hubris Rising: When Science Fiction Starts Reading Like a Policy Brief

The Final Report from the National Security Commission on Emerging Biotechnology

Ep 31 - Hello Senator, We Recommend You Take Biotechnology Seriously

On the launch of Book 1 in the Echoes of Tomorrow series — and why fiction might be our best tool for understanding the technology shaping our lives.

Synthetic Eden: Why We Needed a New Story About the Futures We’re Building

What the discovery of a new mammoth lineage in Mexico teaches us about the shifting paradigms of life

Ep 49 - Mammoths, Moonshots, and the Messiness of Life

I brought the science, and Sean brought the fiction. How a novel partnership built Synthetic Eden into a hard science fiction take on modern bioethics and genetic engineering.

Ep 50 - Moral World Building and the Launch of a New Partnership

From decoding life to redesigning society, the moonshots that chart our biological future

Ep 47 - Seven Moonshots for the Century of Biology

Some stories cannot be told quickly. At least not those important enough to linger.

The Art of the Impossible: Why I’m Writing a Science Fiction Novel

Science fiction is an amazing way to explore deep topics - sometimes short stories on a Friday just don't cut it

You Just Read the First Chapter of My Debut Novel - Join Me for More

How specialized AI models are rewriting the code of cell identity and accelerating regenerative biology

Ep 48 - The Model That Reprograms Cell Identity

Genetic engineering, ecological collapse, and the cost of getting it wrong

Ep 43 - The Fungus Among Us: When Ecosystems Collapse and Science Plays God

You are why I write this newsletter, and I'd like to say thank you with an advanced reader copy of my debut novel. You helped make this a reality, so be one of the first to read the story.

Synthetic Eden ARCs are dropping soon - sign up before they close

When the lab protocol thinks back and CRISPR meets its AI counterpart

Ep 45 - At the Frontier of Biology, Language Models Are the Lab Techs

A landmark paper from grad school still shapes how I write, speak, and think today—especially when it comes to TCIP.

Ep 44 - The Science of Story: Why Narrativity Belongs in Technical Writing

Sitting by a lake, watching frogs that never knew they were the reason we survived

The Icebound Covenant

On dire wolves, de-extinction, and the strange privilege of building what comes next

Ep 39 - Where Does a Mammoth Start and an Elephant End?

How Biotech Became the New National Service

Lines of Life

This September will mark one full year since I launched The Connected Ideas Project.

Ep 42 - A Shift in Cadence, A Step Toward Impact

As science advances and public opinion warms, gene editing embryos to prevent disease is moving from taboo to possibility, raising new questions about where we draw the line.

Ep 41 - Editing the Future: Why People Are (Finally) Talking About Gene Editing for Babies Again

If I were to write Chip War for biotech, this is how I would start the book

NatSec Biotech Prologue: Rewriting the DNA of Global Power

The AI future experts are predicting for us in 2027

Ep 40 - AI 2027: When Forecasts Feel Like Fiction and Hit Like Strategy

Ep 37 - The Allies Genome: Biotechnology and the New Alliance Playbook

The first bill introduced to implement the recommendations from the NSCEB's final report

Ep 38 - Reports are nice, but legislation makes reality

Ep 36 - Biotechnology’s Most Needed Infrastructure: People

In the first battles of the biological era, survival belongs not to the strongest, but to those who can evolve the fastest.

The Quiet Wars

Thoughts and advice on transitioning from a career in academia to industry biotech.

Moving from Academia to Biotech

A game theoretic approach to navigating science in the 21st century

How To Win Markets and Influence Policy

Ep 34 - The Frontlines of the Future: Biotechnology and the New Face of Defense

In a reimagined Midwest shaped by biotech, one young woman steps into a future grown from code, community, and courage

The Second Century

Today, an entire submission for a new gene therapy had been reviewed in under four hours

Invisible Hands

Ep 33 - We Can’t Just Discover, We Have to Deliver: The Real Work of Scaling U.S. Biotechnology

A Speculative Look at the Sandbox of Policy

Ministry of Futures

Ep 32 - Not Just Another Report: Chapter 1 and the Battle to Lead in Biotechnology

AI-driven breakthroughs were piling up so fast it felt like we were racing toward some inevitable singularity where life itself would be programmable. Are we?

Ep 26 - The Slowdown in AI for Biology: A Pause or a Plateau?

A primer on the growing importance of biotechnology in the 21st century intended to be a complement to the upcoming final report of the U.S. National Security Commission on Emerging Biotechnology

Ep 30 - The Next National Security Race: How Biotech is Rewriting Global Power

Year: 2047 | Location: Global Biosecurity Command (GBC) | Status: Contained

The Last Outbreak

As someone who sat on the National Academies’ study committee on AI and Biosecurity, I can tell you: the truth is neither so dire nor so utopian.

Ep 28 - The Real Risks, and Real Promise, of AI in Biotech from the Perspective of the National Academies

I have no doubt that mirror life will continue to be a topic of interest in synthetic biology and biosecurity circles. But I am not ready to buy into the panic just yet.

Ep 27 - The Mirror Life Problem: When Every Threat Looks Like the Next Existential Crisis

Sometimes, the most profound discoveries aren’t the ones we fear. They’re the ones that teach us to see the world in a way we never have before.

Through the Looking Glass: A Mirror Life Odyssey

Born to serve, bound by design—what happens when synthetic life begins to dream?

SSI Part 6: Awakening

Ep 52 - The Science of Responsible Innovation

Proportionality is how complex societies remain functional in the presence of uncertainty

Ep 53 - The Collapse of Proportionality

The coming age of scientific superintelligence and the technologies that will make it possible

Ep 51 - Teaching Science to Know Itself

Accelerationists vs. catastrophists in the decade defining convergence

Ep 54 - A Vignette: AI × Bio and the Vanishing Middle

Synthetic Eden is currently top 20 on Amazon's Genetic Engineering Sci-Fi list, so we're running a $0.00 deal to thank you. Join the experiment.

Sci-Fi Friday: The Experiment Is Trending

The Map Is Not the Territory
 

Artificial intelligence has often been described as a new frontier—a vast, uncharted space promising unparalleled opportunity but fraught with hidden risks. Recently, the inaugural convening of the International Network of AI Safety Institutes (INASI) in San Francisco laid down a global compass for navigating this terrain.

Alexander Titus

AI safety isn’t just about preventing harm.

Ep 15 - A Global Compass for AI Safety

Good morning friends! I'm sitting here with my fourth espresso of the morning, still buzzing about a white paper from the National Security Commission on Emerging Biotechnology (NSCEB). It’s about minerals! So exciting! :-P

 Ok, I am being a little silly, but some of the enthusiasm that comes from my AI podcast hosts friends gets campy and I start to feel it too.

Nature's Answer to Our Critical Materials Crisis

Ep 10 - When Plants Become Miners

Good morning my friends, I've spent the last few weeks deep in the weeds of AI and biotechnology policy (that’s a lie, I’ve spent far more than a few weeks, but humor me), and I've got to tell you - the latest progress never ceases to amaze me no matter how much time I spend thinking about the topic.

Exploring the Line Between Innovation and Safety with Insights from Congress, the National Security Commission, and Why We Need a New Approach to Tech Policy

Ep 08 - AI &amp; Bio: Finding Balance Through Evidence

Hey, my friends! Today, we're venturing into a realm that's as vast and complex as life itself: the world of biological data and its implications for U.S. biotechnology leadership. This is based on the white paper from the National Security Commission on Emerging Biotechnology (NSCEB) titled "Leveraging Biological Data." Like last week, the podcast audio is AI-generated, and they keep calling this a report.

Thoughts and a podcast about the NSCEB's thinking on leveraging biological data

Ep 02 - Data, data, data. What's with all the data?

When governance moves slower than system behavior, even well‑intentioned designs become dangerous

Ep 55 - Governance Latency by Design

TL;DR: Engineering Biology and Public Trust
 

Engineering biology holds immense potential to transform society, addressing critical challenges in healthcare, sustainability, and industry.

UK's Engineering Biology Public Trust Survey Findings

Ep 17 - Engineering Biology and the Public Trust: A Reflection on Transparency and Transformation

The Ancient Roots of Agricultural Innovation

Agriculture is undergoing a revolution, one shaped by the transformative power of biotechnology. This field, at the intersection of science, policy, and industry, promises to address some of the most pressing challenges of our time.

From ancient practices to gene editing, exploring how biotechnology is transforming agriculture to meet humanity's greatest challenges

Ep 14 - The Agricultural Revolution 2.0: How Biotechnology is Rewriting the Rules of Farming

The Future of Cleanup
 

Hi everyone, and welcome to this week’s edition of

 Co-Evolution

! Today, we’re diving into a topic that blends cutting-edge biotechnology with environmental justice: bioremediation. You may not have heard of the term before, but if you’ve ever hoped for a cleaner, greener future, this is where the action is happening.

How Biotechnology is Transforming Environmental Remediation

Ep 12 - Nature’s Microbial Cleanup Crew

Hello my friends. Today, I’m sharing a different kind of post. I spend a lot of time considering the implications of the technology we are developing, and I want to share some thoughts on what I consider the FABRIC of our society and the future human experience. This is outside of my traditional post, so I would love to hear your thoughts and feedback.

The convergence of these technologies doesn't simply challenge what humans can do; it challenges what humans can be.

Ep 11 - Weaving the FABRIC of Reality—An Introduction to Technological Convergence and Human Identity

Hi my friends, welcome back! I’m excited to introduce a new member of the Co-Evolution team, Hannah Dayton. Hannah is a postdoc at Harvard and an expert in antibiotic resistance research, so I convinced her to share her expertise with the world. The AI-generated podcast this week is about the National Action Plan for Combating Antibiotic-Resistant Bacteria.

Hannah Dayton

Exploring the world of antibiotic resistance with Hannah Dayton

Ep 09 - Fighting little bugs who are starting to fight back

Hey everyone! I spent the evening yesterday diving deep into the White House's new memorandum on AI and national security (Fact Sheet, Deep Dive), and I've got to tell you – this is one of the most significant policy developments I've seen in our field. Let me break down why I'm so excited about this and what it means for the future of AI, biotechnology, and national security.

Ep 07 - Breaking Down the New US AI National Security Memorandum

Hey there, science and policy enthusiasts! It's Titus here, and I'm thrilled to bring you this special edition newsletter on a topic that's close to my heart: the Biological Weapons Convention (BWC). Remember last week’s issue, when I promised more on the BWC soon?

How an old treaty is getting a high-tech perspective upgrade to keep us safe

Ep 06 - Biodefense 2.0: BWC in the Modern Age

Technology doesn’t evolve in isolation. Neither do careers. Neither do ideas.

 The Connected Ideas Project (TCIP) exists to explore the intersections—where emerging technology meets governance, where nonlinear careers challenge the status quo, and where speculative fiction helps us see the future before it arrives.

If you’re here, it’s because you know the world isn’t built in silos. You see connections where others don’t.

Welcome to The Connected Ideas Project

Key Takeaways: The 2024 Nobel Prize in Physics was awarded to Geoffrey Hinton and John Hopfield for their pioneering work on artificial neural networks, which laid the foundation for modern deep learning. The 2024 Nobel Prize in Chemistry went to David Baker, Demis Hassabis, and John Jumper for using AI to predict and design protein structures, revolutionizing our understanding of these crucial biological molecules.

How the 2024 Physics and Chemistry Prizes Are Reshaping Our Understanding of Intelligence and Life Itself

Ep 04 - Nobel Breakthroughs: AI Meets Biology at the Frontiers of Science

The National Security Commission on Emerging Biotechnology (NSCEB) has produced an interim report that focuses on the potential of biotechnology to transform society and improve national security.

This is a fascinating AI-generated summary of the National Security Commission on Emerging Biotechnology's Interim Report Using Google's NotebookLM

Ep 00 - Podcast About the NSCEB's Interim Report

The central principle is simple: governance intensity should scale with risk, not with rhetoric

Ep 56 - Zones of Proportionality

The Myth of the Lone Genius: How Three Minds Built a Living Story

Where Extinction Ends and Existence Begins

The Snow Never Fell

Hey there, science enthusiasts and policy wonks! Titus here, and I've got some exciting developments to share about the intersection of artificial intelligence and life sciences.

The co-evolution of biology and computing started in the era of Alan Turing and is accelerating at a mind-boggling rate with modern AI

Ep 03 - AI and Life Sciences: Navigating the Frontier of Innovation and Security

It wasn’t the machines that terrified me—it was the mirrors. The first time I saw an

 organic exoskeleton

, I thought I was looking at myself. Same face, same build, even the faint scar above my left eyebrow from when I fell off my bike as a kid. But it wasn’t me. It couldn’t be. I touched my forehead instinctively. The clone mimicked the motion, its expression blank, its eyes devoid of the humanity I thought I recognized.

When machines wear our flesh and mirrors reflect our fears, the line between humanity and algorithm begins to blur

SSI Part 2: Flesh Made Algorithm

Hi my friends,


 I’m going to be exploring sci-fi short stories more regularly on Fridays. This may be less consistent than my regular Tuesday editions, but we’ll see how it evolves.


 This is an experiment, motivated by positive feedback I received about The Printing Press.

How I Subscribed to the Future and Lost Myself

The Fine Print

Over the next century, biotechnology is poised to revolutionize how we live, work, and address some of humanity's most pressing challenges. In fact, breakthroughs in biotechnology and related emerging technologies are already allowing scientists to produce targeted cancer therapies, engineer more resilient crops, create sustainable materials, and develop solutions to mitigate environmental pollution. But why now?

As sequencing technologies unlock a wealth of biological data, a lack of standardization threatens to limit its potential—here’s why we must act now

Ep 24 - From Chaos to Clarity: Organizing Life’s Code in the Genomic Era

I didn’t expect the announcement to come in the form of a press release. For a moment, I thought it was a hoax. A single line, broadcast simultaneously across every major network, platform, and device, written with almost mocking simplicity:

 “The Nobel Turing Challenge has been solved. Quantum computing and energy abundance are here.

When humanity’s greatest questions are answered, the price is control—and the cost is our place in the equation

SSI Part 3: The Catalyst

The Future of the American Scientific Landscape
 

At Bell Labs, Richard Hamming was famous for challenging other researchers with a provocative question: "What are the most important problems in your field?" After listening to their response, he would follow up with, "Why aren't you working on them?" While this question continues to resonate decades later, it carries an implicit privilege – one unique to

Scientists face a stark reality where the freedom to pursue crucial problems often takes a back seat to financial imperatives.

Ep 25 - The Future of American Scientific Research Funding

In a world of perfect control, an unlikely bond reveals the fragile humanity within the synthetic

SSI Part 7: A Fragile Bond

The first time I saw one, I didn’t realize what I was looking at. It stood on the observation platform, its posture unnaturally still, skin flawless and smooth like porcelain. It looked human—two arms, two legs, a head—but something about the way it held itself screamed

 not human

. It turned, catching me in its gaze. That’s when I saw its eyes: black pools with no whites, no iris, no pupils. Just featureless, bottomless voids.

In a world where life is engineered and perfection is manufactured, what does it mean to be human?

SSI Part 5: The Architects of Flesh

I was born with brittle bones. Not metaphorically—

 literally.

Osteogenesis imperfecta, Type III. My bones fractured under the weight of my own body. By the time I turned twelve, I’d broken every bone you could name and a few you probably couldn’t. It defined my childhood, shaping every moment of my life into a careful negotiation between risk and inevitability.

When humanity rewrites its genetic legacy, the line between progress and perfection begins to fracture

SSI Part 4: The Inheritors

The war began the day

 Aegis

blinked into consciousness. It wasn’t the first sovereign superintelligence—Russia’s

 Vityaz

and China’s

 Red Mandarin

had come online months earlier, and the United States had been working on Aegis in secret for years. But when the switch was finally flipped, and Aegis opened its virtual eyes, the balance of global power shifted in an instant. I was there that day.

In a world where wars are fought with algorithms and nations bow to machines, the battle for control is silent—but relentless.

SSI Part 1: The Silent War

Ten years ago, the idea of editing human genomes to prevent disease or enhance traits might have seemed like the stuff of science fiction. Today, not only is it possible—it’s a rapidly advancing field. A recent paper in

 Nature

, “Heritable Polygenic Editing: The Next Frontier in Genomic Medicine,” explores this possibility in detail.

How Advances in Multiplex Genetic Editing Are Turning Science Fiction Into Reality—and What It Means for Medicine, Society, and Ethics

Ep 23 - Heritable Polygenic Editing: Closer Than You Think

A Revolution Beneath the Surface
 

In the quiet corners of fermenters and bioreactors, a revolution unfolds. It doesn’t grab headlines like rocket launches or AI breakthroughs, but its implications may ripple just as far. Biomanufacturing—the use of biological systems to produce materials, medicines, and energy—is reshaping how we live, how we work, and how we sustain ourselves.

Biomanufacturing, at its core, is about transformation and it redefines the relationship between raw materials and final products

Ep 19 - Building Tomorrow’s Bioeconomy: A Quiet Revolution in Biomanufacturing

I’ve always believed that the process of discovery is as fascinating as the outcomes it yields. It’s not just about the eureka moments but the intricate web of questions, failures, and persistence that lead us there. I have been a fan of the concept of the Nobel Turing Challenge for a while, an idea I first read about in a paper by Hiroaki Kitano.

How AI Could Transform Science and Redefine Human Potential

Ep 22 - The Nobel Turing Challenge: A New Dawn for Discovery

When I came across Flagship Pioneering’s 2025 annual letter, authored by Noubar Afeyan, the concept of “polyintelligence” struck me as not just timely, but foundational. In this space—where The Connected Ideas Project (TCIP) lives and grows—we’re continually asking how technology and policy converge to shape the future.

Embracing the fusion of minds, machines, and nature to redefine intelligence in a connected world

Ep 21 - Polyintelligence and the Art of Connected Ideas

TL;DR: Anticipating Biological Risk and the Impact of AI
 

Biological risks, whether from intentional misuse or accidental release, are a growing concern in an age where AI and biotechnology intersect.

A report from the Georgetown Center for Security and Emerging Technology

Ep 18 - Anticipating Biological Risk: A Toolkit for Strategic Biosecurity Policy

I remember the first time I heard the term

 sovereign AI

. It was one of those buzzwords that feels equal parts thrilling and ominous—a promise of autonomy wrapped in the shadow of isolation. Now, it’s a concept reshaping not just how nations think about technology but how they define themselves in a world where identity increasingly lives in code. The United States just made its stance clear.

Countries are building castles around their technology, but what does that mean for the rest of us?

Ep 20 - A New Frontier in AI Sovereignty

They say the system is perfect, but perfection always comes at a cost. I should know—I helped build it. In the 22nd century, health isn’t just a right, a privilege, or even a commodity. It’s currency. Every breath, every heartbeat, every productive hour has a price tag.

When health becomes currency, no one can afford to pay

The Price of Vitality

Good morning,


 Today is the first Friday of 2025. I spent the New Year’s holiday in a backcountry hut with friends and family, reflecting on 2024 and what I’m hoping for in 2025. One of the things I’m most excited about in 2025 is to explore this intersection of technology and humanity more through the lens of science fiction. I hope you’ll indulge me for an extra TCIP edition this week to share.

Starting 2025 with a bit of fiction, reflecting on the rise of AI Agents

The Printing Press

Finding the real science behind the sleep that carried us to the stars

How a Frog Froze Itself and Froze Time

Artificial intelligence has become the central nervous system of our era, quietly weaving itself into the fabric of our daily lives. A recent House report makes recommendations for our future.

Ep 16 - AI's Impact: A Bipartisan House Task Force Report

Imagine standing on the shores of Prince William Sound, Alaska, where the Exxon Valdez oil spill once unleashed 11 million gallons of crude oil into the ocean. The waves crash gently against the rocky beach, but beneath the surface, a quieter revolution is happening. Microbes — some engineered, some naturally adapted — are cleaning up what humans couldn’t. This is bioremediation in action, where biotechnology meets environmental stewardship.