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Nigam Shah has created the necessary PPM/PPD distribution files for bioperl-1.2 .1 that will allow ActiveState perl users on Windows machines to easily install the bioperl suite and the most common bioperl external module dependencies. The PPD file is online at http://bioperl.org/ftp/DIST/Bioperl-1.2.1.ppd.

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The release is available at http://www.bioperl.org/ftp/DIST/bioperl-1.2.1.tar.gz and is propagating around CPAN now. The main bug fixes in this release are: - inclusion of WrapperBase, making StandAloneBlast work from the release - fixes and cleanup of Bio::Coordinate - fixes to Bio::Index::EMBL and bpindex The 1.2.1 release does see some major additions in the Ontology area.

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We need you! Please download and help test a potential 1.2.1 release candidate that is available at http://bioperl.org/ftp/birney/bioperl-1.2.1-rc2.tar.gz If all goes well the official bioperl-1.2.1 will be released early next week.

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GO::TermFinder will take a list of genes (any name that appears in an annotation file will do, though there are caveats for ambiguous names), an ontology file, and an annotation file, and determine the P_values for the observed frequency of annotation to those genes for each GO node.

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A new mailing list has been created for discussion of software system for genotypes, pedigrees, and linkage data at /mailman/listinfo/bioped-l This is intended to build off the initial work done in Perl for bioperl-pedigree but is applicable to all who want to contribute to the design or implementation in any language. Database persistence and pedigree rendering are initial areas that will be addressed.

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A release candidate for an eventual Bioperl 1.2.1 release is online at: http://bioperl.org/ftp/birney/bioperl-1.2.1-rc1.tar.gz We need people to install and test this package on as many systems and architectures as possible.

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Members of the caCORE team at the NCICB have been discussing if and how best to use LSIDs. Attached is an analysis of the two LSID Resolution proposals. The document also includes brief descriptions of two use cases that seem appropriate to us. We would be very interested in any responses to this analysis.

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MOBY PROJECT: TECHNICAL REPORT ON WEB MESSAGING LAYER Date: March 9, 2003 Author: Lincoln Stein Version: 1.0 This report concerns the messaging layer of the Moby project, that point at which semantic information is exchanged between the data consumer (the biologist or client process) and the data provider (the model organism system database). Full report can be read at: http://open-bio.org/pipermail/moby-l/2003-March/000433.html