Dr. Phil Lackey is retiring from Wake Forest University School of Medicine after many years of service to the school and the community. True to his amazing character, he was on service during his final week of work. Dr. Lackey has been an instrumental part of expanding our activities in High Resolution Anoscopy(HRA) and has been a great mentor to many of our students, residents, and fellows.
Dr Brinkley Bellotti was recently interviewed by the MIT Technology Review on the topic of H5N1 and its continued spread in dairy cows and poultry. In her interview, Dr Bellotti mentions that unmitigated spread of H5N1 in animals could lead to recombination events of the influenza virus which could allow for strains that could more easily infect humans.
Antimicrobial Awareness Week 2024 U.S. Antibiotic Awareness Week (AAW) is observed each year from November 18-24. The purpose of AAW is to raise awareness of the importance of appropriate antibiotic and antifungal use and the threat antimicrobial resistance poses to people, animals, plants and in our environment. See the CDC for more at here.
Most thyroid fine-needle aspirates fit neatly into one of the 6 categories of the Bethesda classification. But sometimes, cases are not so easy and it is worth thinking outside the boxes! This case was one of the latter. Although the targeted nodule was located in the thyroid gland in a patient with a history of thyroid nodules, something didn’t quite fit.
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The Section on Infectious Diseases and the Atrium Health Division of Infectious Diseases attended IDWeek 2024 in Los Angeles, CA and made a strong showing. Presentations and posters were presented by a variety of members including infectious diseases pharmacists, pharmacy residents, medical residents,infectious disease fellows, and infectious disease physicians.
Although Thoracic SMARCA4-deficient undifferentiated tumour (SD-UT) is a recognized entity in the 5th edition of the WHO classification of thoracic tumors, this alteration occurs in garden-variety lung cancer as well (and in many other tumors too!) In fact, it is likely SD-UT exists on a continuum with SMARCA4 -deficient lung cancer. I recently came across an interesting case that demonstrated this phenomenon.
Michael DeWitt attended the 2024 International Field Epidemiology and Tropical Medicine course in Peru hosted by the Universidad Peruana Cayetano Heredia and the EMERGE group(Unidad de Investigación en Enfermedades Emergentes y Cambio Climático) along with students and faculty from the University of Texas Medical Branch.
I collaborated on this study by Dilhan Perera and colleagues, under the direction of Momar Ndao. The article, published in iScience, explores the effects of prior BCG exposure on the effectiveness in mice of an intranasal adenovirus-based vaccine against SARS-Cov-2, the virus that causes COVID-19. I was involved in the scoring of lung damage seen in sacrificed mice from the various experimental groups.
The list of tumours with fusions involving the FET ( EWSR1 , FUS ) and CREB ( CREB1 , ATF1 , or CREM ) families of genes is ever-expanding. These are promiscuous genes that drive neoplasia in a wide variety of anatomical sites, often without being recognized as such – but that doesn’t mean tumours with these molecular lesions are always primary to the location where they are found!