A review of sorts, of questionable objectivity. Forty-eight minutes, so grab some popcorn and settle in. Or run screaming. Up to you!

Back in 2022, I was hyped about Retrieval-Augmented Generation (RAG).The novelty of seeing a search engine spit out a direct answer — with citations! — in tools like Elicit and Perplexity felt like the future. I even predicted that this “answers-with-citations” model could become the prominent paradigm for academic search. Three years later, that prediction has partly come true.

This week’s recap highlights nanoMDBG for metagenome assembly from nanopore reads, the SCassist AI-based workflow for single-cell analysis, discovery and characterization of GxE and GxG effects in a vertebrate model, the PIGEON framework for estimating gene-environment interaction for polygenic traits, and long-read alignment with multi-level parallelism.

Join me for an advanced reader copy of Synthetic Eden and be one of the first in the world to read my full debut novel

Birthdays, BOSC, Beatles and Bioinformatics with a Merseybeat Conference season is upon us, and the GigaScience team have just returned from a magical mystery tour to Liverpool. Regular readers will know GigaScience launched at the ISMB (International Conference on Intelligent Systems for Molecular Biology) in 2012, and every year we attend and celebrate our birthday at the meeting.

After much reflection, the time has come for me to retire, effective at the end of this year. This marks the end of a deeply fulfilling chapter in my life — one filled with purpose, collaboration, and a shared commitment to open knowledge and community-driven progress in open source, open access publishing. I’ve been fortunate to work with so many brilliant people over the years, and I’m extremely proud of what we’ve achieved together.

Wie wird aus einem geförderten Pilotprojekt eine dauerhaft tragfähige Infrastruktur? Diese zentrale Frage stellten sich viele der Teilnehmenden des Hands-on-Labs „Vom Drittmittelprojekt über die Community zur etablierten Struktur – Erfahrungsaustausch und Erarbeitung von Empfehlungen“ (Arning et al. 2025) auf dem 9. Bibliothekskongress / der 113. Bibliocon in Bremen am 26.06.2025.

The DinoCon brochure — really a conference guidebook, with schedule, speaker list, vendor list, maps, etc. — is a free download here. Art by Natalia Jagielska. DinoCon is right around the corner, the weekend of August 16-17. The speaker lineup looks fantastic, and the vendor lineup looks like it will execute a Chicxulub on my wallet. On the speaker side, I’m happy to see sauropods getting so much representation.

I’ve written several times here about the Make Data Count project and its major output to date, the Data Citation Corpus, currently at version 4 (see The fourth release of the Data Citation Corpus incorporates data citations from Europe PMC and additions to affiliation metadata). In June Make Data Count launched a Kaggle Competition with the goal of developing a tool that will process articles (in either PDF or XML format), extract data

BIOinformación para investigación y práctica digital en BIOtecnología Recientemente hemos recibido un buen número de estudiantes de biotecnología  interesados en realizar su servicio social, su práctica profesional o su tesis en el laboratorio de BIOinformación. La biotecnología investiga e innova en las aplicaciones técnicas de la biología (Ng &

Introduction AI has evolved drastically over time. AI agents started off as elementary programs based on if-then rules without any extra learning capabilities. They were reactive . You give them an input, they give something back. Early chatbots, spam filters all fell under this category.